| Study title | Meta-analysis of the effects of flaxseed interventions on blood lipids |
|---|---|
| Publication year | 2009 |
| Authors | Pan A, Yu D, Demark-Wahnefried W, et al. |
| DOI | 10.3945/ajcn.2009.27469 |
| PubMed ID | 19515737 |
| Study design |
|
| Number of participants | 1.500 |
| Population | Adults with normal cholesterol or dyslipidemia |
| Intervention | Whole flaxseed, ground flaxseed, flax lignan supplements, or flaxseed oil |
| Comparator | Placebo or control diet |
| Duration | 2–52 weeks |
| Health claim | Flaxseed reduces LDL cholesterol |
| Outcome measured | LDL cholesterol, total cholesterol, HDL cholesterol, triglycerides |
| Main result | Flaxseed interventions significantly reduced LDL cholesterol and total cholesterol. Whole flaxseed and lignan supplements were more effective than flaxseed oil, with greater benefits in women and participants with higher baseline cholesterol. |
| Risk of bias | Moderate |
| Funding | Not industry-sponsored; supported by academic/public research funding |
| Citation | Pan A, Yu D, Demark-Wahnefried W, et al. Meta-analysis of the effects of flaxseed interventions on blood lipids. Am J Clin Nutr. 2009;90(2):288-297. doi:10.3945/ajcn.2009.27469. |