| Study title | Flaxseed supplemented foods lower blood pressure and improve lipid profile in patients with peripheral artery disease (FLAX-PAD Trial) |
|---|---|
| Publication year | 2013 |
| Authors | Rodriguez-Leyva D, Weighell W, Edel AL, et al. |
| DOI | 10.1161/HYPERTENSIONAHA.113.02094 |
| PubMed ID | 24243790 |
| Study design |
|
| Number of participants | 110 |
| Population | Adults with peripheral artery disease |
| Intervention | Foods containing 30 g/day milled flaxseed |
| Comparator | Matching placebo foods |
| Duration | 6 months |
| Health claim | Flaxseed improves cardiovascular risk factors including LDL cholesterol |
| Outcome measured | LDL cholesterol, total cholesterol, blood pressure, plasma ALA |
| Main result | LDL cholesterol decreased modestly, while systolic and diastolic blood pressure were significantly reduced. Plasma alpha-linolenic acid increased substantially, confirming adherence. |
| Risk of bias | Low |
| Funding | Canadian Institutes of Health Research (CIHR) and Heart & Stroke Foundation of Canada |
| Citation | Rodriguez-Leyva D, Weighell W, Edel AL, et al. Potent antihypertensive action of dietary flaxseed in hypertensive patients. Hypertension. 2013;62(6):1081-1089. doi:10.1161/HYPERTENSIONAHA.113.02094. |